Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants
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چکیده
منابع مشابه
matrix metalloproteinases and breast cancer
results based on the recent researches, certain mmps play critical role in breast cancer initiation, invasion, and metastasis. they can be regarded as predictive biomarkers of primary diagnosis and prognosis of breast cancer and have predictive value for evaluation of disease, tumor recurrence, invading of tumor cells to other sites and therapeutic outcomes. conclusions in summary, the results ...
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Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. MMPs have been demonstrated to increase the permeability of the blood–brain barrier (BBB) by degrading the c...
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Muscular exercise promotes the production of radicals and other reactive oxygen species in the working muscle. Growing evidence indicates that reactive oxygen species are responsible for exercise-induced protein oxidation and contribute to muscle fatigue. To protect against exercise-induced oxidative injury, muscle cells contain complex endogenous cellular defence mechanisms (enzymatic and non-...
متن کاملMatrix metalloproteinases
What makes an MMP an MMP? They all have a conserved zinc-binding site in their catalytic domain (HEXGHXXGXXH), and the sequence PRCGVPD in the propeptide domain. The cysteine residue serves to anchor the propeptide to the catalytic zinc, suppressing enzymatic activity in a manner that is not unlike a thumb in an open mouth. Release of this interaction results in proteolytic activity. MMPs are a...
متن کاملMatrix Metalloproteinases.
Matrix metalloproteinases are a family of highly regulated peptidases that are collectively responsible for the degradation of extracellular matrix during tissue remodeling. Dysregulated activity has long been implicated in the pathologies of cancer and arthritis, and the number of diseases more recently associated with these enzymes has been increasing. In the past year, new transgenic models ...
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ژورنال
عنوان ژورنال: World Journal of Biological Chemistry
سال: 2014
ISSN: 1949-8454
DOI: 10.4331/wjbc.v5.i3.355